Bad News About Agave Nectar, Honey, and other Concentrated Fructose Sweeteners - August 12, 2010
This is all bad news, so I shall keep it short and not sweet at all. I have previously reported that sugar, especially sucrose (table sugar) and glucose (regular corn syrup) should be strictly avoided by cancer warriors. I further suggested that High Fructose Corn Syrup (HFCS) should also be avoided, as it is chemically about the same as table sugar (sucrose is 50/50 glucose and fructose while HFCS ranges from 45/55 to 40/60) while saving your body even the small work of breaking one chemical bond that unites these two simple sugars in sucrose. The reason I gave for this is that intake of these high-glucose sweeteners will spike your blood sugar and super-energize cancer cells by showering them with their favorite food source. Clear, recent, peer-reviewed evidence supports the fact that HFCS is more dangerous than table sugar. Alternatives that I suggested were honey and agave nectar, both forms of fructose (also known as fruit sugar). Some new research from UCLA has indicated that fructose is particularly evil for cancer warriors, even though it does NOT spike blood glucose and is therefore safe for diabetics. The reason is that when the fructose eventually enters a cancer cell, it turns out that the cancer actually PREFERS the fructose for non-oxidative respiration (fermentation), leading to bad side effects like inflammation, uric acid, and healthy/happy cancer cells. While the research article was based only on the particularly nasty pancreatic cancer, it is well known that ALL cancers metabolize sugars in identical fashion.
This is a very unpleasant surprise to those of us who found agave nectar to be a "free pass" to sugar sweetness (and calories) without the risk. So even though Oprah puts agave nectar in her oatmeal (a fact that has driven demand high and promoted widespread availability), cancer is well fed by fructose. My cousin who lives in Mexico, a few miles from the area where most agave nectar is sourced, has also passed on some information that very nasty chemicals are often used in conjunction with making the "nectar," adding to the risk of using it as food. And the amount of fructose naturally occurring in fruit is not large enough to be of concern, but fruit juice (which has the equivalent of way more fruit than you could eat in a sitting) is also a path to high fructose intake. So it looks like Stevia or very limited amounts of organic table sugar, brown sugar, or pure maple syrup are the only alternatives at this point. Honey should be used only in the strictest moderation. Artificial sweeteners? Don't even think about messing with these highly processed chemicals. Safest would be nothing at all.
Please read the comments below this post for some interesting further discussions about fructose and stevia.
Steve, I have been using Stevia since back when you printed the article on sweetners. Thank goodness there is still a sweetner safe to use. Next judgement for me in October. Mike
Always full of great though sometimes disturbing information Steve, thank you. I was reading through some of my emails and this jumped out and hit me between the eyes all about Fructose so youumay wish to add to your arsenal of articles http://articles.mercola.com/sites/articles/archive/2010/08/27/warning--fructose-feeds-cancer-cells.aspx Additionally I followed up on Mike's notes about Stevia - it is banned here in the UK and Europe - to find out why see here http://www.food.gov.uk/multimedia/webpage/stevia
Thanks, David, for the helpful additions. I pored eagerly over the information found on the stevia link you provided. It seems the EU has banned stevia, not because of the presence of valid data to show it is harmful, but rather the absence of valid data (in their somewhat narrow view) to show it is "safe." In the USA it is permitted as an unregulated food supplement, but forbidden as a food additive in most cases - this prohibition is being slowly lifted as more and more stevia-containing food products clear the hurdles in the USA.
Oddly, the EU allows the distribution and use of cyclamates, an excellent artificial sweetener, which has been banned in the USA for over 40 years. Even though I have some, I no longer use it or any artificial sweetener - simply as a precautionary method to avoid any potential carcinogens.
Canada allows both stevia and cyclamates. So whose nanny-state is the most effective? I suppose that is a matter of personal preference.
I am aware of the mercola site and agree with some of his conclusions. But I find Dr. Mercola's approach to be rife with conflict of interest and his style of fear-mongering to be particularly offensive. Readers beware!
Steve, Thanks for your comments, I just want to add that Fructose has never been an option to avoid calories or all the problems generates from regular sugar. Stevia is the better choice by the moment. Nevertheless I Have been in factories in Mexico (Jalisco) that produces Agave Nectar and believe me, in all the process they never use any chemical products .. The juices are extracted in cold press, then filtered, demineralized, evaporated and that´s it... The only advantage of Agave Nectar from other sweeteners is the Low Glycemic index ... Matthew
Regarding the material about sweeteners, here are two internet addresses with interesting research papers concerning honey.
http://www.ncbi.nlm.nih.gov/pubmed/12657101
CONCLUSION: Bee honey is an effective agent for inhibiting the growth of T24, RT4, 253J and MBT-2 bladder cancer cell lines in vitro. It is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models. Our results are promising, and further research is needed to clarify the mechanisms of the antitumor activity of honey.
https://www.mdpi.com/1420-3049/19/2/2497/pdf
Conclusions Honey is a natural product that shows potential effects to inhibit or suppress the development and progression of tumor and cancer. Its antiproliferative, antitumor, antimetastic and anticancer effects are mediated via diverse mechanisms, including cell cycle arrest, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling, and inhibition of angiogenesis in cancer cells. Honey is highly and selectively cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. It can inhibit cancerogenesis by modulating or interfering with the molecular processes or events of initiation, promotion, and progression stages. It, therefore, can be considered a potential and promising anticancer agent which warrants further research—both in experimental and clinical studies
Need to contact me? Use the photo-link near the bottom of this column.
Had an interesting annual checkup - no cysto, but ultrasound and blood/urine tests. Bottom line ALL CLEAR now 14 years and counting! God is good!
My parents were from a generation that feared seat belts. In May of 2013 they were both ejected from their vehicle (my father would have said "thrown clear") and did not survive. Automobile safety technology has dramatically improved since the 1950s and 1960s.
People, if you are traveling over 35mph, WEAR YOUR SEAT BELTS!
BLADDER CANCER ROLL CALL
Recent Results
2022
ME! - Steve K. in Bodrum, Türkiye ALL CLEAR on June 10. - 14 yrs
Wil S. in Chicago ALL CLEAR on March 22. - 15 months HK in Toronto ALL CLEAR on Feb 5. - 13+ years
2021
Steven S. in Tennessee ALL CLEAR on Oct 27. - 10 years Roy B. in Alabama ALL CLEAR on May 4. - 9 yrs Scott in South Carolina ALL CLEAR on April 20. - 6.5 yrs
2020
David F. in England ALL CLEAR on October 2 - 14.25 yrs and finished with cystos now!
2019
Julie M. in Illinois ALL CLEAR on June 15. - 8+ yrs
Roy B. in Alabama ALL CLEAR on June 24. - 8 yrs
2018
Ed B. in Washington ALL CLEAR January (but battling lung cancer now). - 9 yrs Bladder Cancer Free Patrick P. in LA area ALL Clear on November 28. - 9 years Sebastián in Argentina ALL CLEAR on October 9. - 5 yrs John B. in Minnesota ALL CLEAR on May 24. - 5 yrs Doug B. in Tennessee ALL CLEAR on April 7. - 3 yrs Ben F. In Louisiana ALL CLEAR on Feb 22. - 6 yrs
Need to contact me? Use the photo-link near the bottom of this column.
Short Summary of My Situation
On March 31, 2008 I was diagnosed with bladder cancer. As a non-smoker, at my age, with no family history of cancer on either side, I was quite surprised. The cancer was T1-G3 and Non-Invasive. It's not immediately life threatening, but my bladder is still at risk. I have been CANCER FREE via surgery for 14 years now, an important number - having exceeded both the two year ultra-high-risk and 10 year medium-risk recurrence periods. Less than 2% chance of the cancer returning now, not zero, so lifetime annual cystoscopies are in order. In addition I have completed 6 weekly treatments of initial BCG immunotherapy and nine 3-week maintenance rounds with moderately unpleasant side-effects. I have implemented radical dietary changes (limited pork, shellfish, sugar, ZERO artificial sweeteners (except stevia), processed flours, or chlorinated water), take several vitamins and supplements including the Budwig Flax Oil Cottage Cheese (FOCC) mix, resumed PectaSol-C MCP,and added regular light exercise.
Every year my doctor will visually inspect for new cancer growth via cystoscope, or a combination of ultrasound with blood and urine tests. While the probability of recurrence is not zero, the risk of disease progression is dramatically decreased now. The downside picture is merely a nuisance. Annual checkups for life. And any new cancer leads to another TURBT surgery to remove and analyze what's there. Probably nothing more beyond increased surveillance after that.
I have pursued an analytical approach to Complementary Therapies - those that can be done IN ADDITION TO what the doctors are doing. There are over 200 "unproven" approaches out there, and some work sometimes. I have conducted an objective, systems-based analysis many of them to determine which ones work under which conditions, looking for common, science-based threads. My current set of things I am doing is described in detail in this post.
All diagnosis, prognosis, and medical treatment recommendations have been validated with second opinions from a urologist in Indiana and Dr. Lamm in Arizona.
I am a great fan of life and doing something useful with the limited time we have on this earth. I enjoy my church, my home life, and my retirement.
My hobbies include extensive international travel, experiencing new cultures, and consuming fine food and wine (both at home and dining out).
On March 31, 2008, I received the very unwelcome news, "You've got bladder cancer!"
I was born in 1959, and I am a white, male, American. I married at age 24, and in October of 2008 we celebrated our 25th anniversary. We have no children, and that's OK with us. I had a vasectomy in 1999, so no changing minds on that decision - and the docs dismissed that early as any type of contributor to the situation.
I am six feet, zero inches, and was 255 pounds when all this started, but weight decreasing now thanks to surgeries and this wake-up call. I am NOT saying cancer comes from being overweight, but weight exacerbates all other problems. (Down to 240 pounds as of 9/1/08, down to 230 pounds as of 12/31/08, down to 220 as of 5/15/09, but back up to 230 and holding since...)
My blood pressure (checked and tracked weekly) runs a hair high - 130/90. Been steady at that level for many years. Been higher lately - stress will do that.
I don't smoke, and never have smoked anything, including marijuana. The docs had some problem believing me, as smoking is a strong indicator for bladder cancer. I tried asking if I should take it up now to break even, and they finally let it go. I find the whole idea of smoking distasteful, having suffered in a home where both parents favored unfiltered Pall Malls. The docs claim that secondhand smoke at home from birth through my high school years would not be a factor.
They also suggest that exposure to radiation and chemicals can cause this. I worked in a chem lab at college and there was stuff around; but my exposure was not that much and I never rubbed my groin on any of it!
I do enjoy an occasional alcoholic drink - usually a couple of glasses of wine with dinner or maybe a beer or two with pizza or during a televised sporting event. My use is less than daily and almost never more than two in any day.
I was diagnosed with gout in 2004. Gout is a crystallization of uric acid in the joints - primarily in the left big toe. These crystals cause irritation and inflammation - then BIG TIME PAIN. Gout supposedly comes from eating rich foods and poor circulation. I may also have a recessive gene for gluten sensitivity which may have contributed; but I have not as yet investigated this. I controlled the gout successfully for a while by super-hydrating (one gallon plus of fluids per day) but 4 international trips proved that I could not maintain or control this outside of home and an air-conditioned office. So in 2006 I began taking 75mg of allopurinol daily. This is also NOT a factor for bladder cancer. Subsequently I changed my diet and lifestyle and lost a lot of weight. Now I am not taking any medication for gout, nor have I had an episode in many years.
5 comments:
Steve, I have been using Stevia since back when you printed the article on sweetners. Thank goodness there is still a sweetner safe to use.
Next judgement for me in October.
Mike
Always full of great though sometimes disturbing information Steve, thank you. I was reading through some of my emails and this jumped out and hit me between the eyes all about Fructose so youumay wish to add to your arsenal of articles http://articles.mercola.com/sites/articles/archive/2010/08/27/warning--fructose-feeds-cancer-cells.aspx
Additionally I followed up on Mike's notes about Stevia - it is banned here in the UK and Europe - to find out why see here http://www.food.gov.uk/multimedia/webpage/stevia
Thanks, David, for the helpful additions. I pored eagerly over the information found on the stevia link you provided. It seems the EU has banned stevia, not because of the presence of valid data to show it is harmful, but rather the absence of valid data (in their somewhat narrow view) to show it is "safe." In the USA it is permitted as an unregulated food supplement, but forbidden as a food additive in most cases - this prohibition is being slowly lifted as more and more stevia-containing food products clear the hurdles in the USA.
Oddly, the EU allows the distribution and use of cyclamates, an excellent artificial sweetener, which has been banned in the USA for over 40 years. Even though I have some, I no longer use it or any artificial sweetener - simply as a precautionary method to avoid any potential carcinogens.
Canada allows both stevia and cyclamates. So whose nanny-state is the most effective? I suppose that is a matter of personal preference.
I am aware of the mercola site and agree with some of his conclusions. But I find Dr. Mercola's approach to be rife with conflict of interest and his style of fear-mongering to be particularly offensive. Readers beware!
Steve, Thanks for your comments, I just want to add that Fructose has never been an option to avoid calories or all the problems generates from regular sugar. Stevia is the better choice by the moment. Nevertheless I Have been in factories in Mexico (Jalisco) that produces Agave Nectar and believe me, in all the process they never use any chemical products .. The juices are extracted in cold press, then filtered, demineralized, evaporated and that´s it... The only advantage of Agave Nectar from other sweeteners is the Low Glycemic index ... Matthew
Regarding the material about sweeteners, here are two internet addresses with interesting research papers concerning honey.
http://www.ncbi.nlm.nih.gov/pubmed/12657101
CONCLUSION:
Bee honey is an effective agent for inhibiting the growth of T24, RT4, 253J and MBT-2 bladder cancer cell lines in vitro. It is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models. Our results are promising, and further research is needed to clarify the mechanisms of the antitumor activity of honey.
https://www.mdpi.com/1420-3049/19/2/2497/pdf
Conclusions
Honey is a natural product that shows potential effects to inhibit or suppress the development and
progression of tumor and cancer. Its antiproliferative, antitumor, antimetastic and anticancer effects are
mediated via diverse mechanisms, including cell cycle arrest, activation of mitochondrial pathway,
induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of
oxidative stress, amelioration of inflammation, modulation of insulin signaling, and inhibition of
angiogenesis in cancer cells. Honey is highly and selectively cytotoxic against tumor or cancer cells
while it is non-cytotoxic to normal cells. It can inhibit cancerogenesis by modulating or interfering
with the molecular processes or events of initiation, promotion, and progression stages. It, therefore,
can be considered a potential and promising anticancer agent which warrants further research—both in
experimental and clinical studies
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